CD62P, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD62P, Human |
| Clone | REA389 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD62P Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA389 recognizes the human CD62P antigen, a 140 kDa single-pass type I membrane protein also known as P-selectin or platelet activation dependent granule-external membrane protein (PADGEM). CD62P is expressed by vascular endothelial cells and platelets. The protein is stored preformed in the Weibel-Palade bodies of endothelial cells and in the α-granules of platelets. Upon stimulation of these cells with a variety of agonists such as thrombin or histamine, CD62P is rapidly translocated to the cell surface, where it mediates leukocyte-platelet and leukocyte-vascular endothelial cell adhesion. The interaction of CD62P with mature leukocytes is in part responsible for mediating leukocyte rolling on vascular cells - an early event in leukocyte recruitment at sites of inflammation. In addition to its role as a receptor for mature neutrophils and monocytes, CD62P also functions as a cell adhesion molecule for leukocyte precursor cells in the bone marrow, including both lineage-restricted clonogenic progenitors and hierarchically more primitive progenitor cells. | Additional information: Clone REA389 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | SELP, CD62, GMP-140, GRMP, LECAM3, PADGEM, PSEL, P-selectin |
| Gene, Accession # | Gene ID: 6403 |
| Catalog # | 130-120-725 |
| Price | $360 |
| Order / More Info | CD62P, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Zannettino, A. C. et al. (1995) Primitive human hematopoietic progenitors adhere to P-selectin (CD62P). Blood 3466 (3477): 85-12. | Johnston, G. I. et al. (1989) Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation. Cell 56 (6): 1033-1044. | Wickenhauser, C. et al. (2000) Selectins (CD62L, CD62P) and megakaryocytic glycoproteins (CD41a, CD42b) mediate megakaryocyte-fibroblast interactions in human bone marrow. Leuk. Res. 24 (12): 1013-1021. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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