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Antigenic Specificity | CD206, Human |
Clone | DCN228 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1κ |
Format | fluorescein (FITC) conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD206 Antibody, anti-human, FITC. The mannose receptor (MR), also known as macrophage MR or CD206, is a 162-175 kDa type I membrane protein. It contains an N-terminal cystein-rich domain and eight C-type lectin-like domains (CTLDs), beside a transmembrane and a cytoplasmic domain. CD206 is expressed by macrophages, dendritic cells, and subsets of endothelial cells, but not on monocytes. The MR recognizes multiple mainly microbial carbohydrates with mannose, fucose, or N-acetyl glucosamine residues. The MR mediates endocytosis and phagocytosis, linked to antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. |
Immunogen | n/a |
Other Names | MRC1, CLEC13D, CLEC13DL, MMR, MRC1L1 |
Gene, Accession # | Gene ID: 4360 |
Catalog # | 130-123-671 |
Price | $265 |
Order / More Info | CD206, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Tacken, P. J. et al. (2005) Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody. Blood 106: 1278-1285. | Ezekowitz, R. A. B. et al. (1990) Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. J. Exp. Med. 172: 1785-1794. | Kang, P. B. et al. (2005) The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J. Exp. Med. 202: 987-999. | Sallusto, F. et al. (1995) Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartement: downregulation by cytokines and bacterial products.? J. Exp. Med. 182: 389-400. | Wileman, T. E. et al. (1986) Identification of the macrophage mannose receptor as a 175-kDa membrane protein. Proc. Natl. Acad. Sci. U.S.A. 83: 2501-2505. | Feinberg, H. et al. (2000) Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. J. Biol. Chem. 275: 21539-21548. | Lennartz, M. R. et al. (1989) Biosynthesis and processing of the mannose receptor in human macrophages. J. Biol. Chem. 264: 2385-2390. | Ng, Y. S. (2012) Chemical transfection of dye-conjugated microRNA precursors for microRNA functional analysis of M2 macrophages. J. Cell. Biochem. 113 (5): 1714-1723. |