CD360 (IL-21R), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD360 (IL-21R), Human |
| Clone | REA233 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD360 (IL-21R) Antibody, anti-human, PE, REAfinity™. Clone REA233 recognizes CD360, which is also known as interleukin 21 (IL-21) receptor. CD360 forms a heterodimer with the common γ subunit, which is shared by other receptors such as IL-2 and IL-15 receptor and serves as the receptor for IL-21. CD360 is a single-pass type I membrane protein and belongs to the type I cytokine receptor family. Expression of CD360 is found on variety of cells including B cells, NK cells subsets, T cells, NKT cells, dendritic cells, macrophages, and non-hematopoietic cells such as keratinocytes and fibroblasts. CD360 is composed of the cytokine-binding domain, a transmembrane domain and a large intracellular domain that contains conserved structural motifs, including the commonly described box 1 and box 2 elements, which are important for signal transduction. IL-21 mediated signaling plays vital role in mediating immune response and is involved in enhancement of adaptive T cell-immunity, antibody production, activation of natural killer cell subtypes, and opposing the suppressive effects mediated by regulatory T cells. | Additional information: Clone REA233 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | IL21R, NILR |
| Gene, Accession # | Gene ID: 50615 |
| Catalog # | 130-126-121 |
| Price | $149 |
| Order / More Info | CD360 (IL-21R), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Lowe, L. et al. (2011) IL-21R is critical for the development of memory responses. J Immunol 186: 150. | Hamming, O. J. et al. (2012) Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. J. Biol. Chem. 287: 9454-9460. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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