c-Rel, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | c-Rel, Mouse |
| Clone | REA397 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | c-Rel Antibody, anti-mouse, APC, REAfinity™. Clone REA397 recognizes the mouse c-Rel antigen, a 65 kDa member of the NF-κB family of eukaryotic transcription factors, which also includes the proteins RelA (p65), RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). NF-κB transcription factors can form various homo- and heterodimers possessing unique specificities in regulating target gene expression. While RelA-containing dimers are present in most cell types, c-Rel complexes are predominately found in cells of hematopoietic origin. In T cell lymphocytes, certain genes essential for immune function such as interleukin 2 (IL-2) and FoxP3 are directly regulated by c-Rel. Additionally, c-Rel-dependent IL-12 and IL-23 transcription by macrophages and dendritic cells (DCs) is crucial for T cell differentiation and effector functions. Accordingly, c-Rel expression in T cells and antigen-presenting cells controls a delicate balance between tolerance and immunity. | Additional information: Clone REA397 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | REL |
| Gene, Accession # | Gene ID: 19696 |
| Catalog # | 130-106-188 |
| Price | $66 |
| Order / More Info | c-Rel, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Gilmore, T. D. et al. (2004) The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene 23 (13): 2275-2286. | Grumont, R. J. et al. (1990) The murine c-rel proto-oncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli. Oncogene 5 (4): 245-254. | Gonzalez-Perez, G. et al. (2017) Gastrointestinal microbiome dysbiosis in infant mice alters peripheral CD8+ T cell receptor signaling. Front Immunol 8: 265. | Gonzalez-Perez, G. and Lamouse-Smith, E. S. (2017) Gastrointestinal microbiome dysbiosis in infant mice alters peripheral CD8+ T cell receptor signaling. Front Immunol 8 (8): 265. | Visekruna, A. et al. (2012) A key role for NF-κB transcription factor c-Rel in T-lymphocyte-differentiation and effector functions. Clin. Dev. Immunol. 2012: 239368. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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