CD184 (CXCR4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD184 (CXCR4), Human |
| Clone | 12G5 |
| Host Species | Mouse |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG2aκ |
| Format | PE-Vio 770 conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD184 (CXCR4) Antibody, anti-human, PE-Vio® 770. The monoclonal antibody 12G5 recognizes human CD184, also known as CXCR4 or fusin, a 45 kDa seven transmembrane G-protein-linked chemokine receptor for SDF-1. CXCR4 is ubiquitously expressed on blood and tissue cells. It mediates chemotaxis in mature and progenitor blood cells and is important for B lympho- and myelopoiesis and cardiogenesis. It is reported to block CD4-independent HIV-2 infection and CD4-dependent infection by some T cell tropic isolates of HIV-1. |
| Immunogen | n/a |
| Other Names | CXCR4, LAP-3, LCR1, LESTR, NPY3R, WHIM, WHIMS, Fusin |
| Gene, Accession # | Gene ID: 7852 |
| Catalog # | 130-103-798 |
| Price | $350 |
| Order / More Info | CD184 (CXCR4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ichiyama, K. et al. (2003) A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. Proc. Natl. Acad. Sci. U.S.A. 100: 4185-4190. | Berger, E. A. et al. (1999) Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 17: 657-700. | Loetscher, P. et al. (2000) Chemokines and their receptors in lymphocyte traffic and HIV infection. Adv. Immunol. 74: 127-180. | McKnight, A. et al. (1997) Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent. J. Virol. 71 (2): 1692-1696. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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