EOMES, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | EOMES, Mouse |
| Clone | REA116 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | EOMES Antibody, anti-mouse, APC, REAfinity™. Clone REA116 recognizes EOMES, also known as T-box brain protein 2 (TBr2) or eomesodermin. EOMES is a 72-74 kDa T-box transcription factor and plays a crucial role in development including trophoblast differentiation, gastrulation, brain development, and cell-mediated immunity in adults. EOMES lacking embryos are arrested at the blastocyst stage due to differentiation defects of the trophoectoderm. As a regulator of cell mediated immunity, expression of EOMES is shown to be increased in effector CD8+ T cells, in response to infection. Further, EOMES including its paralogue T-bet are suggested to be involved in NK cell maturation. | Additional information: Clone REA116 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | TBR-2 |
| Gene, Accession # | Gene ID: 13813 |
| Catalog # | 130-123-819 |
| Price | $91 |
| Order / More Info | EOMES, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Gordon, S. M. et al. (2012) The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity 36 (1): 55-67. | Pearce, E. L. et al. (2003) Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science 302: 1041. | Kidder, B. L. et al. (2010) Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res. 20: 458-472. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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