CD283 (TLR3), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD283 (TLR3), Human |
| Clone | TLR 3.7 |
| Host Species | Mouse |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1κ |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:10 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD283 (TLR3) Antibody, anti-human, APC. The monoclonal antibody TLR 3.7 reacts with CD283, also known as toll-like receptor 3 (TLR3). Toll-like receptors are a family of pattern recognition receptors that have evolved to detect components of foreign pathogens referred to as pathogenassociated molecular patterns. TLR3 is a single-pass type I membrane protein expressed exclusively in intracellular vesicles, such as the endoplasmic reticulum (ER), endosomes, lysosomes, and endolysosomes, where it recognizes microbial dsRNA. Multiple cell types are known to express TLR3 including dendritic cells, keratinocytes, and neurons. TLR3 activates via the TRIF-dependent pathway antiviral immune responses through the production of type I interferon and inflammatory cytokines, suggesting that TLR3 has an essential role in the prevention of viral infection. |
| Immunogen | n/a |
| Other Names | TLR3, IIAE2 |
| Gene, Accession # | Gene ID: 7098 |
| Catalog # | 130-096-885 |
| Price | $325 |
| Order / More Info | CD283 (TLR3), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Visintin, A. et al. (2001) Regulation of Toll-like receptors in human monocytes and dendritic cells. J Immunol 166: 249. | Sonali, K. and Reinhardt, T. A. (2005) Increased expression of TLR3 in lymph nodes during simian immunodeficiency virus infection: implications for inflammation and immunodeficiency. J Immunol 175: 5314-5323. | Alexopoulou, L. et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 (6587): 732-738. | Oshiumi, H. et al. (2003) TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction. Nat Immunol 4: 161-167. | Rock, F. L. et al. (1998) A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. U.S.A. 95: 588-593. | Matsumoto, M. et al. (2002) Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem. Biophys. Res. Commun. 293: 1364-1369. | Jorgenson, R. L. et al. (2005) Human endometrial epithelial cells cyclically express toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA. Hum. Immunol. 66 (5): 469-482. | de Bouteiller, O. et al. (2005) Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH. J. Biol. Chem. 280: 38133-38145. | Lafon, M. et al. (2006) The innate immune facet of brain: human neurons express TLR-3 and sense vial dsRNA. J. Mol. Neurosci. 29: 185-194. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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