STAT1 pS727, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | STAT1 pS727, Human |
| Clone | REA525 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | STAT1 pS727 Antibody, anti-human, PE, REAfinity™. Clone REA525 recognizes the signal transducer and activator of transcription 1 (STAT1) antigen phosphorylated at serine 727 (pS727). STAT1 expression is found ubiquitously. It is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. STAT1 is an essential transcription factor for macrophage activation by IFN-γ and requires phosphorylation of the C-terminal pS727 for transcriptional activity. It forms homodimers or heterodimers with STAT3 that bind to the IFN-γ activated sequence promoter element. In response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the interferon stimulated response promoter element. In either case, binding of the promoter element leads to an increased expression of interferon stimulated genes. | Additional information: Clone REA525 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91 |
| Gene, Accession # | Gene ID: 6772 |
| Catalog # | 130-107-988 |
| Price | $110 |
| Order / More Info | STAT1 pS727, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kovarik, P. et al. (1999) Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 96 (24): 13956-13961. | Vanhatupa, S. et al. (2008) MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1. Biochem. J. 409 (1): 179-185. | Luu, K. et al. (2014) STAT1 plays a role in TLR signal transduction and inflammatory responses. Immunol. Cell Biol. 92 (9): 761-769. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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