TCRγ/δ, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TCRγ/δ, Human |
| Clone | 11F2 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1κ |
| Format | fluorescein (FITC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TCRγ/δ Antibody, anti-human, FITC. The T cell receptor is a heterodimeric glycoprotein associated with the CD3 antigen. The TCR consists of an α and a β chain (TCRα/β) or a γ and a δ chain (TCRγ/δ). Clone 11F2 reacts with a framework epitope of the γ/δ T cell-receptor. The γ and δ TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. The γ chain forms either disulfide-linked or non-disulfide-linked heterodimers with the δ-subunit.The γ/δ Tcell-receptor is present on a subset of T lymphocytes in peripheral blood, intestinal epithelium, lymph node, thymus, and spleen. TCR γ/δ is involved in the recognition of certain bacterial, self-CD1 molecule, and tumor antigens bound to MHC class I. γ/δ T cells are mainly CD4 negative and CD8 negative. T cells expressing the γ/δ TCR have been shown to play a role in oral tolerance, innate immune response for some tumor cells, and autoimmune disease. Antigen presentation by γ/δ T cells has been reported. |
| Immunogen | n/a |
| Other Names | TRD, TCRD, TCRDV1, TRD@, TCRG, TRG@, TRG |
| Gene, Accession # | Gene ID: 6965 |
| Catalog # | 130-113-503 |
| Price | $275 |
| Order / More Info | TCRγ/δ, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Spencer, C. T. et al. (2008) Only a subset of phosphoantigen-responsive gamma9delta2 T cells mediate protective tuberculosis immunity. J Immunol 181 (7): 4471-4484. | Voogt, P. J. et al. (1989) Normal hematopoietic progenitor cells and malignant lymphohematopoietic cells show different susceptibility to direct cell-mediated MHC-non-restricted lysis by T cell receptor-/CD3-, T cell receptor gamma delta+/CD3+ and T cell receptor-alpha beta+/CD3+ lymphocytes. J Immunol 142 (5): 1774-1780. | Borst, J. et al. (1988) Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody. J. Exp. Med. 167 (5): 1625-1644. | Lanier, L. L. et al. (1987) The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer. J. Exp. Med. 165 (4): 1076-1094. | Conrad, M. L. et al. (2007) TCR and CD3 antibody cross-reactivity in 44 species. Cytometry A 71 (11): 925-933. | Lanier, L. L. et al. (1988) Structural and serological heterogeneity of γ/δ T cell antigen receptor expression in thymus and peripheral blood. Eur. J. Immunol. 18 (12): 1985-1992. | Testi, R. and Lanier, L. L. (1989) Functional expression of CD28 on T cell antigen receptor gamma/delta-bearing T lymphocytes. Eur. J. Immunol. 19 (1): 185-188. | Lanier, L. L. et al. (1987) The gamma T-cell antigen receptor. J. Clin. Immunol. 7 (6): 429-440. | Moens, E. et al. (2011) IL-23R and TCR signaling drives the generation of neonatal Vγ9 Vδ2 T cells expressing high levels of cytotoxic mediators and producing IFN-γ and IL-17. J. Leukoc. Biol. 89 (5): 743-752. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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