GLAST (ACSA-1), Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | GLAST (ACSA-1), Human/Mouse/Rat |
| Clone | ACSA-1 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG2aκ |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | GLAST (ACSA-1) Antibody, anti-human/mouse/rat, PE. The antibody ACSA-1 (astrocyte cell surface antigen-1) is specific for an extracellular epitope of the astrocyte specific transmembrane glycoprotein GLAST in the central nervous system (CNS). Besides GLT-1, GLAST is the most abundant glutamate transporter and is predominantly expressed by astrocytes in the developing and neonatal mammalian CNS. Also radial glia, which belong to the astrocyte lineage and play important roles in development, are known to express GLAST. Postnatally, radial glia only persist in a few regions, such as Bermann glia in the cerebellum, Mueller glia in the retina, and radial glia in the dentate gyrus of the adult hippocampus. |
| Immunogen | n/a |
| Other Names | SLC1A3, EA6, EAAT1, GLAST1 |
| Gene, Accession # | n/a |
| Catalog # | 130-118-344 |
| Price | $315 |
| Order / More Info | GLAST (ACSA-1), Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Storck, T. et al. (1992) Structure, expression, and functional analysis of a Na+-dependent glutamate/aspartate transporter from rat brain. Proc. Natl. Acad. Sci. U.S.A. 8 (22): 10955-10959. | Kriegstein, A. R. and Gotz, M. (2003) Radial glia diversity: a matter of cell fate. Glia 43: 37-43. | Wahle, S. and Stoffel, W. (1996) Membrane topology of the high-affinity L-glutamate transporter (GLAST- 1) of the central nervous system. J. Cell Biol. 135 (6): 1867-1877. | Morris, L. G. et al. (2013) Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat. Genet. 45 (3): 253-261. | Jackson, W. S. et al. (2014) Translation of the prion protein mRNA is robust in astrocytes but does not amplify during reactive astrocytosis in the mouse brain. PLoS One 9 (4): e95958. | Kimelberg, H. K. (2004) The problem of astrocyte identity. Neurochem. Int. 45 (2-3): 191-202. | Mich, J. K. et al. (2014) Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. Elife 3: e02669. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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