AN2, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | AN2, Human/Mouse |
| Clone | 1E6.4 |
| Host Species | Rat |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | AN2 Antibody, anti-human/mouse, Biotin. AN2 is the mouse homolog of the rat NG2 and human MCSP proteins. NG2 is a chondroitin sulfate glycoprotein that is expressed by glial progenitor cells in the developing and adult central nervous system (CNS) and by immature Schwann cells. NG2/AN2+ glia has been identified as a fourth major glial cell type in the mammalian CNS that is distinct from other cell types. NG2/AN2+ cells are precursors of oligodendrocytes and some protoplasmic astrocytes in the gray matter. NG2/AN2 expression is down-regulated before the cells undergo terminal differentiation. However, a population of NG2/AN2+ cells remains in the white and gray matter after oligodendrocytes are generated. NG2/AN2+ glial cells participate in neuron-glial circuits by receiving presynaptic input from neurons and responding to neurotransmitters released by synapses. Many highly migratory neural tumors including melanomas express NG2/AN2. |
| Immunogen | n/a |
| Other Names | CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2 |
| Gene, Accession # | Gene ID: 1464 |
| Catalog # | 130-097-456 |
| Price | $264 |
| Order / More Info | AN2, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Trotter, J. et al. (2010) NG2 cells: Properties, progeny and origin. Brain Res. Rev. 63: 72-82. | Zhu, X. et al. (2008) NG2 cells generate both oligodendrocytes and gray matter astrocytes. Development 135 (1): 145-157. | Zhu, X. et al. (2011) Age-dependent fate and lineage restriction of single NG2 cells. Development 138: 745-753. | Diers-Fenger, M. et al. (2001) AN2/NG2 protein-expressing glial progenitor cells in the murine CNS: isolation, differentiation, and association with radial glia. Glia 34: 213-228. | Wigley, R. et al. (2007) Morphological and physiological interactions of NG2-glia with astrocytes and neurons. J. Anat. 210: 661-670. | Stegmuller, J. et al. (2002) AN2, the mouse homologue of NG2, is a surface antigen on glial precursor cells implicated in control of cell migration. J. Neurocytol. 31: 497-505. | Peters, A. (2004) A fourth type of neuroglial cell in the adult central nervous system. J. Neurocytol. 33: 345-357. | Nishiyama, A. et al. (2009) Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity. Nat. Rev. Neurosci. 10: 9-22. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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