CD127, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD127, Mouse |
| Clone | A7R 34 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2aκ |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD127 Antibody, anti-mouse, PE. The antibody clone A7R 34 reacts with CD127, also known as interleukin 7 receptor α chain (IL-7Rα). Mouse CD127 is a 60-90 kDa type I transmembrane glycoprotein. It is a component of the high affinity IL-7 receptor (IL-7R) and the receptor for thymic stromal lymphopoietin (TSLP). CD127 is expressed on immature B cells, CD4-CD8-, CD4+, and CD8+ thymocytes, naive and memory T cells, thymic NK cells, and bone marrow stromal cells. Upon activation of naive T cells, CD127 expression is down-regulated. Re-expression of CD127 identifies the effector cells that will differentiate into memory T cells. |
| Immunogen | n/a |
| Other Names | IL-7R, IL-7Rα |
| Gene, Accession # | Gene ID: 16197 |
| Catalog # | 130-125-101 |
| Price | $68 |
| Order / More Info | CD127, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Colpitts, S. L. et al. (2009) IL-7 receptor expression provides the potential for long-term survival of both CD62Lhigh central memory T cells and T?1 effector cells during Leishmania major infection. J Immunol 182: 5702-5711. | Vosshenrich, C. A. et al. (2006) A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat Immunol 7: 1217-1224. | Kaech, S. M. et al. (2003) Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol 4: 1191-1198. | Park, L. S. et al. (2000) Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J. Exp. Med. 192 (5): 659-670. | Sudo, T. et al. (1993) Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 90: 9125-9129. | Goodwin, R. G. et al. (1990) Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 60: 941-951. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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