CD278 (ICOS), Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD278 (ICOS), Human/Mouse/Rat |
| Clone | REA192 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD278 (ICOS) Antibody, anti-human/mouse/rat, APC, REAfinity™. Clone REA192 recognizes CD278 (ICOS), which belongs to the CD28 family of proteins. CD28 family members are costimulatory receptor molecules, contain single immunoglobulin V-like domain, and belong to the immunoglobulin superfamily. CD287 recognizes inducible T cell costimulator ligand (ICOSL) as ligand and its expression is induced on activated T cells. Enhanced expression of CD278 is also observed on T cells, followed by costimulation of T cells via CD28. Further expression of CD278 is found on B cells, monocytes, and dendritic cells. Crosslinking of ICOS on T cell surface in the presence of primary stimulation signal leads to T cell proliferation and differentiation. In addition, CD278 plays role in T? cell differentiation, effector T cell function, and isotype class switching. | Additional information: Clone REA192 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | ICOS, AILIM, CVID1 |
| Gene, Accession # | Gene ID: 29851, 54167, 64545 |
| Catalog # | 130-100-721 |
| Price | $325 |
| Order / More Info | CD278 (ICOS), Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Akbari, O. et al. (2008) ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol 180: 5448-5456. | Wassink, L. et al. (2004) ICOS expression by activated human T? Cells is enhanced by IL-12 and IL-23: Increased ICOS expression enhances the effector function of both T?1 and T?2 cells. J Immunol 173: 1779-1786. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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