CD30, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD30, Mouse |
| Clone | mCD30.1 |
| Host Species | Hamster |
| Reactive Species | mouse |
| Isotype | IgG1κ |
| Format | phycoerythrin (PE) conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD30 Antibody, anti-mouse, PE. Clone mCD30.1 recognizes mouse CD30, a 105 kDa type I transmembrane glycoprotein, also known as tumor necrosis factor receptor superfamily member 8 (TNFRSF8). CD30 is a cell membrane protein. The cytoplasmic tail has been shown to interact with tumor necrosis factor receptor-associated factor 5 (TRAF5), TRAF1, TRAF2, and TRAF3. CD30 is expressed on the cell surface of activated T, B, and NK cells, and monocytes. The ligand for CD30 is CD153. CD153 co-stimulates peripheral blood T-cell proliferation or apoptosis, induces surface expression of activation and adhesion molecules (e.g., CD54, CD80, and CD86), and induces cytokine (e.g., interleukin 2, tumor necrosis factor, and interferon γ) secretion. Deletion of the murine CD30 gene revealed that CD30 may have a unique role in negative thymic selection following exposure to antigen. |
| Immunogen | n/a |
| Other Names | TNFRSF8, Ki, Ki-1 |
| Gene, Accession # | Gene ID: 21941 |
| Catalog # | 130-103-974 |
| Price | $46 |
| Order / More Info | CD30, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Bowen, M. A. et al. (1996) Structure and expression of murine CD30 and its role in cytokine production. J Immunol 156 (2): 442-449. | Ansieau, S. et al. (1996) Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation. Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14053-14058. | Aizawa, S. et al. (1997) Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. J. Biol. Chem. 272 (4): 2042-2045. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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