VEGFR-3 (FLT-4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | VEGFR-3 (FLT-4), Human |
| Clone | REAL1031 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | fluorescein (FITC) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | VEGFR-3 (FLT-4) Antibody, anti-human, FITC, REAdye_lease™. Clone REAL1031 is an antibody fragment derived from the full VEGFR-3 (FLT-4) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1031 recognizes the human VEGFR-3 (FLT-4) antigen, a Single-pass type I membrane protein known as Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4 (FLT-4) or CD310. VEGFR-3 (FLT-4) is a tyrosine-protein kinase that acts as a cell-surface receptor for the vascular endothelial growth factors VEGF-C and VEGF-D. It plays an essential role in adult lymph-angiogenesis, in the development of the vascular network and the cardiovascular system during embryonic development. During early embryogenesis all endothelial cells express VEGFR-3 (FLT-4), while in the adult tissues, VEGFR-3 (FLT-4) expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. VEGFR-3 (FLT-4) plays a major role in tumor growth and metastatic tumor cell dissemination. The receptor is over-expressed on lymphatic vessels in the vicinity of tumors and on the tumor vasculature and therefore may be an excellent target for an effective cancer intervention. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
| Immunogen | n/a |
| Other Names | FLT-4, Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, CD310 |
| Gene, Accession # | n/a |
| Catalog # | 130-127-944 |
| Price | $400 |
| Order / More Info | VEGFR-3 (FLT-4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Pajusola, K. et al. (1992) FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res. 52 (20): 5738-5743. | Achen, M. G. et al. (1998) Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc. Natl. Acad. Sci. U.S.A. 95 (2): 548-553. | Tammela, T. et al. (2011) VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat. Cell Biol. 13 (10): 1202-1213. | Baker, E. et al. (2019) Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival. Breast Cancer (Auckl) 13: . |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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