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Antigenic Specificity | CD352 (NTB-A), Human |
Clone | REA339 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD352 (NTB-A) Antibody, anti-human, PE, REAfinity™. Clone REA339 recognizes the human CD352 antigen, a 60 kDa single-pass type I membrane protein also known as SLAM family member 6 (SLAM6) or natural killer (NK), T, and B cell-antigen (NTB-A). CD352 belongs to the CD2 subfamily of the immunoglobulin superfamily and is expressed on NK, T, and B cells. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases. Monoclonal antibody-mediated cross-linking of CD352 results in the induction of NK-mediated cytotoxicity. CD352 also triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors. This suggests that CD352 may function as a coreceptor in the process of NK cell activation. Importantly, analysis of NK cells derived from patients with X-linked lymphoproliferative disease showed that the lack of SH2D1A protein profoundly affects the function of CD352. | Additional information: Clone REA339 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | SLAMF6, KALI, KALIb, LY108, NTB-A, NTBA, SF2000, SLAM6, TCOM |
Gene, Accession # | Gene ID: 114836 |
Catalog # | 130-121-051 |
Price | $310 |
Order / More Info | CD352 (NTB-A), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Katz, G. et al. (2014) SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced cell death. J Immunol 192 (9): 4202-4209. | Bottino, C. et al. (2001) NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease. J. Exp. Med. 194 (3): 235-246. | Valdez, P. A. et al. (2004) NTB-A, a new activating receptor in T cells that regulates autoimmune disease. J. Biol. Chem. 279 (18): 18662-18669. |