CD18, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD18, Human |
| Clone | REA1112 |
| Host Species | Recombinant Human |
| Reactive Species | human, other |
| Isotype | IgG1 |
| Format | PE-Vio 615 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD18 Antibody, anti-human, PE-Vio® 615, REAfinity™. Clone REA1112 recognizes the human CD18 antigen, a type I transmembrane protein with an approximate molecular weight of 90-95 kDa. It non-covalently associates with α subunits CD11a (αL), CD11b (αM), CD11c (αX), and CD11d (αD) to form functional integrins which are expressed on leukocytes. CD18 associated integrins bind several ligands including cell surface and extracellular matrix proteins and are involved in cell-cell and cell-extracellular matrix interactions, immune regulation, and immune tolerance. Leucocytes of patients lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation. | Additional information: Clone REA1112 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ITGB2, LAD, LCAMB, LFA-1, Mac-1 α, MF17 |
| Gene, Accession # | Gene ID: 3689 |
| Catalog # | 130-119-264 |
| Price | $162 |
| Order / More Info | CD18, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Barber, D. F. et al. (2004) LFA-1 contributes an early signal for NK cell cytotoxicity. J Immunol 173 (6): 3653-3659. | Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32 (3): 241-269. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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