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Antigenic Specificity | CD321 (JAM1), Human |
Clone | REA605 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | VioBlue conjugate |
Size | 30 tests in 300 µL |
Concentration | 1:11 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD321 (JAM1) Antibody, anti-human, VioBlue®, REAfinity™. Clone REA605 recognizes the human CD321 antigen, a cell-surface adhesion molecule, also known as JAM1 or JAMA. CD321 is a type I transmembrane glycoprotein belonging to the immunoglobin superfamily. It has two extracellular Ig-like domains, a transmembrane region and a short cytosolic tail. | CD321 is expressed on a variety of cell types: erythrocytes, leukocytes, platelets, as well as endothelial and epithelial cells. CD321 has different functions. It is a regulator of tight junction assembly in epithelia and acts as a receptor for reovirus. Furthermore CD321 binds integrin LFA1 and is involved in leukocyte transmigration. In addition, CD321 is a platelet receptor. | Additional information: Clone REA605 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | JAM-1, JAM-A, PAM-1, F11 R |
Gene, Accession # | Gene ID: 50848 |
Catalog # | 130-109-480 |
Price | $144 |
Order / More Info | CD321 (JAM1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Fraemohs, L. et al. (2004) The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain. J Immunol 173 (10): 6259-6264. | Ozaki, H. et al. (1999) Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J Immunol 163 (2): 553-557. | Sobocka, M. B. et al. (2000) Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. Blood 95 (8): 2600-2609. |