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Antigenic Specificity | RNF2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 co |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human RNF2 (NP 009143.1). |
Other Names | [BAP1; DING; BAP-1; HIPI3; RING2; RING1B] |
Gene, Accession # | [RNF2], Gene ID: 6045, NCBI: NP_009143.1, UniProt: Q99496 |
Catalog # | MBS8545654 |
Price | $280 |
Order / More Info | RNF2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |