Edit |   |
Antigenic Specificity | Phospho- STAT5 (pTyr 694) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse, bovine, dog |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | ELISA, Western Blot, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes STAT5 (pY694) with a phosphorylated sites of Tyr694. It does not cross-react with non-phosphospecific peptide. STAT proteins (Signal transducer and activator of transcription) belong to a family of cytoplasmic transcription factors that can be phosphorylated by a lignad binding to its cell surface receptor. STAT5 is tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Serine phosphorylation is also required for maximal transcriptional activity. NCoA-1/SRC-1 acts as a co-activator for both the a- and b-isoforms of STAT5. |
Immunogen | Antigen Preparation: A synthetic peptide surrounding to the epitope -DGYVK-- with phosphorylation sites at Tyr694 of STAT5 protein from human, mouse and rat origins. |
Other Names | [Rabbit Phospho-STAT5 (pY694); Signal transducer and activator of transcription 5 (STAT5)], [stat5a] |
Gene, Accession # | [STAT5 (pY694)], Gene ID: 399176, NCBI: NP_001083890.1 |
Catalog # | MBS462116 |
Price | $285 |
Order / More Info | Phospho- STAT5 (pTyr 694) Antibody from MYBIOSOURCE INC. |
Product Specific References | Lin, J.X., et al. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. J. Biol Chem. 271: 10738, 2006 |