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Antigenic Specificity | OPTN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-577 of human OPTN (NP 068815.2). |
Other Names | [NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP] |
Gene, Accession # | [OPTN], NCBI: Q96CV9.2, UniProt: Q96CV9 |
Catalog # | MBS8544623 |
Price | $280 |
Order / More Info | OPTN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |