Human IL-31 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHuman IL-31
Clone[SB118b1]
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2b
Formatunconjugated
Size0.1 mg
Concentrationn/a
ApplicationsELISA
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DescriptionReacts with native and recombinant human IL-311. Interleukin-31 (IL-31) is a 24kD alpha-helical protein and a member of the IL-6 family of cytokines that is preferentially expressed by CD4+ T cells2. This cytokine elicits its response by binding to a heterodimeric complex consisting of a gp130-like receptor chain and the oncostatin M receptor subunit. On target cells which include a broad range of immune and non-immune cells, IL-31 binding can induce activation of the Jak/STAT, AKT and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles that include regulating hematopoiesis and immune response3,4. Over-expression has been linked chronic inflammatory states such as dermati
ImmunogenImmunogen: Recombinant human IL-31. Characterization: To ensure acceptable performance, each batch of product is tested by ELISA to conform to characteristics of a standard reference reagent.
Other Names[Mouse Human Interleukin-31 (IL-31)], [IL31; IL31; IL-31; IL-31]
Gene, Accession #Gene ID: 386653, NCBI: NP_001014358.1, UniProt: Q6EBC2
Catalog #MBS670218
Price$340
Order / More InfoHuman IL-31 Antibody from MYBIOSOURCE INC.
Product Specific References1) Zhang, Q. et al. (2008). Cyto. Grow. Rev. 19:347-56.3) Broxmeyer, H.E. et al. (2007). Exp. Hematol. 35:78-86.4) Perrigoue, J.G. et al. (2007). J. Exp. Med. 204:481-7.5) Sonkoly, E. et al. (2006). J. All. Clin. Immunol. 117:411-7.6) Dillon, S.R. et al. (2004). Nat. Immunol. 5:752-60.7) Dambacher, J. et al. (2007). Gut. 56:1257-65.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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