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Antigenic Specificity | beta-Catenin (Tyr-142), phospho-specific [gamma-Catenin (Tyr-133)] |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody was cross-adsorbed to phospho-tyrosine coupled to agarose before affinity purification using phospho- beta -Catenin (Tyr-142) peptide (without carrier). The antibody detects a 92kDa* protein corresponding to the molecular mass of beta -Catenin on SDS-PAGE immunoblots of Hct116 src transformed cells treated with pervanadate, but not in control cells. Similar results were observed in other pervanadate-treated cell lines, such as A431 and human endothelial cells. beta-Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions. Deletions in the cytoplasmic domain of ECadherin eliminate catenin binding and result in a l |
Immunogen | Immunogen: Phospho-beta-Catenin (Tyr-142) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 142 of human beta-Catenin. This peptide sequence has one amino acid difference from a sequence around tyrosine 133 of human gamma-Catenin. These human sequences are highly conserved in rat and mouse beta-Catenins. |
Other Names | [b-Catenin (Tyr-142); phospho-specific; Catenin beta], [ctnnb1; ctnnb1; ctnnb; id:ibd2058; wu:fb73e10; wu:fi81c06; wu:fk25h01] |
Gene, Accession # | Gene ID: 30265, UniProt: Q7ZU14 |
Catalog # | MBS472004 |
Price | $385 |
Order / More Info | beta-Catenin (Tyr-142), phospho-specific [gamma-Catenin (Tyr-133)] Antibody from MYBIOSOURCE INC. |
Product Specific References | • Brembeck, F.H. et al. (2004) Genes Dev. 18(18):2225-2230.• Ozawa, M. et al. (1990) Proc. Natl. Acad. Sci. USA 87:4246.• Piedra, J. et al. (2003) Mol. Cell. Biol. 23(7):2287-2297. |