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Antigenic Specificity | ATG4A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 289-398 of human ATG4A (NP 443168.2). |
Other Names | [APG4A; AUTL2] |
Gene, Accession # | [ATG4A], Gene ID: 115201, NCBI: NP_443168.2, UniProt: Q8WYN0 |
Catalog # | MBS8545019 |
Price | $280 |
Order / More Info | ATG4A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |