E-Cadherin (Uvomorulin) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | E-Cadherin (Uvomorulin) |
| Clone | polyclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 5 mL |
| Concentration | n/a |
| Applications | Immunohistochemistry (IHC) Formalin/Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody to E-cadherin is well suited to detect this glycoprotein in different types of epithelia. The localization is usually limited to the lateral cell membrane. E-Cadherin (Uvomorulin, ARC-1) is a Ca2+-dependent trans-membrane protein, which plays an important role for the cell connection in epithelia. Ligands for E-Cadherin are catenins, which bind to actin filaments of the cyto-skeleton. The cell to cell adhesion during embryo genesis is dependent of the interrelation of these three components. Reduced expression of E-Cadherin in carcinoma has been discussed as a factor influencing tumour invasion and bad prognosis of cancer. E-Cadherin 120 kDa. |
| Immunogen | Immunogen: Recombinant human Uvomorulin (Cadherin-E) aa 600-707 |
| Other Names | [E-cadherin, partial; Cadherin-1; cadherin-1; cadherin 1; CAM 120/80; Epithelial cadherin; E-cadherin], [CDH1; CDH1; UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324; CDHE; UVO; E-cadherin] |
| Gene, Accession # | Gene ID: 999, NCBI: CAA84586.1, UniProt: P12830 |
| Catalog # | MBS397040 |
| Price | $415 |
| Order / More Info | E-Cadherin (Uvomorulin) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Frixen U.H., et al. (1991) E-Cadherin-mediated cell-cell adhesion prevents invasivness of human carcinoma cells. J. Cell Biol. 113 ff. 2. Umbas R. Schalken J.A., Aalders T.W., Carter B.S., Karthaus H.F.M., Schaafsma H.E., Debruyne F.M.J., and Isaacs W.B. (1992) Expression of the cellular adhesion molecule E-Cadherin is reduced or absent in high-grade prostate cancer. Cancer Res. 52; 5104-5109. 3. Darai e., Scoazec J.Y., Walker-Combrouze F., Mlika-Cabanne N., Feldmann G., Madelenat P., and F. Potet (1997) Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: a clinicopathologic study of 60 cases. Hum. Pathol. 28(8); 922-928. 4. Ruijter E., van de Kaa C., Aalders T. Ruiter D., Miller G., Debruyne F., and Schalken J. (1998) Heterogeneous expression of E-Cadherin and p53 in prostate cancer: clinical implications. BIOMED-II markers for prostate cancer study group. Mod. Pathol. 11(3); 276-281. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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