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Antigenic Specificity | FLI1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | reacts with: human, rat. predicted to work with: mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (Paraffin-embedded Section) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: No cross reactivity with other proteins. Friend leukemia integration 1 transcription factor, also known as Transcription factor ERGB or Proto-oncogene Fli-1 is a protein that in humans is encoded by the human FLI1 gene. The fli1 protooncogene encodes a member of the ETS family of winged helix-turn-helix transcription factors. This gene is mapped to 11q24.3. Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias. The constitutive activation of fli-1 in erythroblasts leads to a dramatic shift in the Epo/Epo-R signal transduction pathway, blocking erythroid differentiation, activating the Ras pathway, and resulting in massive Epo-independent proliferation of erythroblasts. These res |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human FLI1 (54-73aa QQEWINQPVRVNVKREYDHM), identical to the related rat and mouse sequences. |
Other Names | [Friend leukemia integration 1 transcription factor; Friend leukemia virus integration 1; ERGB transcription factor; Ewing Sarcoma breakpoint region 2; EWSR 2; EWSR2; FLI 1; FLI 1 proto oncogene; FLI1; FLI1 EWS fusion gene; FLI1 proto oncogene; FLI1_HUMAN; Friend leukemia integration 1 transcription factor; Friend leukemia virus integration 1; Proto-oncogene Fli-1; SIC 1; SIC1; Transcription factor ERGB; Viral integration region FLI1], [FLI1; FLI1; EWSR2; SIC-1] |
Gene, Accession # | [FLI1], Gene ID: 2313, NCBI: Q01543.1, UniProt: Q01543 |
Catalog # | MBS177100 |
Price | $315 |
Order / More Info | FLI1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |