Mouse CD5/Ly-1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Mouse CD5/Ly-1 |
| Clone | [B19.1] |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2a kappa |
| Format | unconjugated |
| Size | 0.5 mg |
| Concentration | n/a |
| Applications | Flow Cytometry; Immunohistochemistry (Acetone Fixed/Frozen Sections); Immunoprecipitation; Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: CD5/Lyt-1, Mr 67 kDa. CD5/Lyt-1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells.^1-3 It has been identified as the major ligand of the B-cell antigen CD72.^4, 5 The frequency of CD5^+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells (reviewed in 6). Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression.^7 |
| Immunogen | n/a |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS673168 |
| Price | $235 |
| Order / More Info | Mouse CD5/Ly-1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Ledbetter, J. A. and L. A. Herzenberg. 1979. Immunol. Rev. 47:63.2. Seaman, W. E., D. Wofsy, J. S. Greenspan, and J. A. Ledbetter. 1983. J. Immunol. 130:1713.3. Ledbetter, J. A., R. V. Rouse, H. S. Micklem, and L. A. Herzenberg. 1980. J. Exp. Med. 152:280.4. Van de Veld, H., I. von Hoegen, W. Luo, J. R. Parnes, and K. Thielemans. 1991. Nature 351:662.5. Luo, W., H. Van de Velde, I. von Hoegen, J. R. Parnes, and K. Thielemans. 1992. J. Immunol. 148:1630.6. Kantor, A. B. and L. A. Herzenberg. 1993. Ann. Rev. Immunol. 11:501.7. Holland, N. 1982. Immunol. Rev. 68:43.8. Stanton, T., T. L. Stevens, J. A. Ledbetter, and D. Wofsy. 1986. J. Immunol. 136:1734.9. Verwilghen, J. R., P. Vandesande, and J. L. Ceuppens. 1996. Cell Immunol. 131:109.10. Logdberg, L. and E. M. Shevach. 1996. Eur. J. Immunol. 15:1007.11. June, C. H., P. R. Rabinovitch, and J. A. Ledbetter. 1987. J. Immunol. 138:2782.12. Hollander, N., E. Pillemer, and I. L. Weissman. 1981. Proc. Natl. Acad. Sci. U. S. A. 78:1148.13. Tarakhovsky, A., S.B. Kanner, J. Hombach, J.A. ledbetter, W. Muller, N. Killeen, and K. Rajewsky. 1995. Science 269:535.14. Bikah, G., J. Carey, J.R. Cialella, A. Tarakhovsky, and S, Bobdada. 1996. Science 274:1906.15. Moratz, C. and J. F. Kearney. 1996. Personal communication. |
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MYBIOSOURCE INC.
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