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Antigenic Specificity | Human CD274 |
Clone | [MIH2] |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | IgG concentration 1.0mg/ml |
Applications | Flow cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mouse anti Human CD274 antibody, clone MIH2 detects human CD274, also known as B7-H1 and PD-1L, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to Interferons alpha, beta and gamma. CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of na?ve T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to costimulate |
Immunogen | Immunogen: Human CD274 transfected P815 cells Fusion Partners: Cells from immunised mice were fused with cells of the P3U1 myeloma cell line. Buffer Solution: Phosphate buffered saline Target Species: Human |
Other Names | [programmed cell death 1 ligand 1 isoform b; Programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; B7 homolog 1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1; CD274 molecule; B7 homolog 1; B7-H1; CD_antigen: CD274], [CD274; CD274; B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1; B7H1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7-H1] |
Gene, Accession # | [CD274], Gene ID: 29126, NCBI: NP_001254635.1, UniProt: Q9NZQ7 |
Catalog # | MBS216276 |
Price | $300 |
Order / More Info | Human CD274 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |