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Antigenic Specificity | Hrk |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 15 amino acid peptide from near the center of human Hrk. |
Other Names | [Harakiri, Neuronal death proteinDP] |
Gene, Accession # | [Hrk], Gene ID: 8739, NCBI: NP_003797 |
Catalog # | MBS9410318 |
Price | $320 |
Order / More Info | Hrk Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |