Edit |   |
Antigenic Specificity | Adipophilin |
Clone | polyclonal |
Host Species | Guinea Pig |
Reactive Species | human, mouse, rat, dog, and bovine. reactivity with cultured cell lines: Caco, PLC, Hacat, SV80, RD125, Huvec, RV, PC-12, MDCK. Negative with glioma |
Isotype | n/a |
Format | serum |
Size | 0.1 mL |
Concentration | 100ul per vial |
Applications | Immunohistochemistry (IHC), Immunoblotting |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Human adipophilin. Adipophilin / ADRP (a member of the PAT family) is a ubiquitous component of lipid droplets. It has been found in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines (see e.g. Heid et al.; for review see e.g. Targett-Adams et al.); inducible by etomoxir. Enhanced expression of Adipophilin / ADRP is a useful marker for pathologies characterized by increased lipid droplet accumulation. Such diseases include atheroma, steatosis, obesity and certain cases of liposarcoma. It also seems to be a potent marker for atherosclerosis. |
Immunogen | Immunogen: Synthetic peptide (N-terminal aa 1-29 of human and murine adipophilin). Assay Information: Adipocytes are negative. Also positively stained are lipid-storing CD 68-positive macrophages. |
Other Names | [Adipophilin; Adipophilin], [PLIN2; PLIN2; ADFP; ADRP; ADFP; ADRP] |
Gene, Accession # | Gene ID: 123, NCBI: CAA65989.1, UniProt: Q99541 |
Catalog # | MBS534652 |
Price | $605 |
Order / More Info | Adipophilin Antibody from MYBIOSOURCE INC. |
Product Specific References | Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones; Jie Donga, Tammy Tonga, Amanda M. Reynadoa, Jeffrey M. Rosenb, Shixia Huangb, Yi Li (Developmental Biology: Volume: 346 Issue: 2 Page: 196-203 DOI: 10.1016/j.ydbio.2010.07.027) |