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Antigenic Specificity | Atg4C |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. |
Immunogen | Immunogen: A synthesized peptide derived from human Atg4C Subcellular Localization: Cytoplasm. Tissue Specificity: Highly expressed in skeletal muscle, heart, liver and testis. |
Other Names | [Cysteine protease ATG4C; 3.4.22.-; AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; ATG4C; APG4C; AUTL1; AUTL3] |
Gene, Accession # | [Atg4C], Gene ID: 84938, NCBI: NP_116241.2, UniProt: Q96DT6 |
Catalog # | MBS1750116 |
Price | $160, $340, $340 |
Order / More Info | Atg4C Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |