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Antigenic Specificity | HDAC2 (Center) |
Clone | [1194CT18.5.1] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This HDAC2 antibody is generated from a mouse immunized with a recombinant protein between 202-488 amino acids from the Central region of human HDAC2. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. De |
Immunogen | n/a |
Other Names | [Histone deacetylase 2; HD2; HDAC2] |
Gene, Accession # | [HDAC2], Gene ID: 3066, NCBI: NP_001518.3, UniProt: Q92769 |
Catalog # | MBS9200475 |
Price | $165, $370 |
Order / More Info | HDAC2 (Center) Antibody from MYBIOSOURCE INC. |
Product Specific References | Yang W.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:12845-12850(1996). Ota T.,et al.Nat. Genet. 36:40-45(2004). Mungall A.J.,et al.Nature 425:805-811(2003). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Schmidt D.R.,et al.Biochemistry 38:14711-14717(1999). |