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Antigenic Specificity | TNFR1 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: TNFR1 Antibody detects endogenous levels of TNFR1. TNF-R1 Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. |
Immunogen | Immunogen: A synthesized peptide derived from human TNFR1 |
Other Names | [CD120a; FPF; MGC19588; p55; p55-R; p60; TBP1; TBPI; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-RI; TNFAR; TNFR-I; TNFR1; TNFR55; TNFR60; TNFRSF1A; TNR1A; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor 1; tumor necrosis factor receptor] |
Gene, Accession # | [TNFR1], Gene ID: 7132, NCBI: NP_001056.1, UniProt: P19438 |
Catalog # | MBS8510776 |
Price | $290 |
Order / More Info | TNFR1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |