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Antigenic Specificity | CHAF1A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CHAF1A (NP 005474.2). |
Other Names | [CAF1; P150; CAF-1; CAF1B; CAF1P150] |
Gene, Accession # | [CHAF1A], Gene ID: 10036, NCBI: NP_005474.2, UniProt: Q13111 |
Catalog # | MBS8544884 |
Price | $280 |
Order / More Info | CHAF1A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |