Smad4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Smad4 |
| Clone | [5B8-F7-F3] |
| Host Species | Mouse |
| Reactive Species | human, rat |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Entrez Summary: Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily; SMAD4 is the common SMAD (co-SMAD). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. May act as a tumor suppressor?Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. UniPort Summary Function: In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by |
| Immunogen | Immunogen: Purified recombinant fragment of human SMAD4 expressed in E Coli. Sequence Similarities: Contains 1 MH2 (MAD homology 2) domain. |
| Other Names | [JIP; DPC4; MADH4; SMAD4], [JIP; DPC4; MADH4; SMAD4] |
| Gene, Accession # | [Smad4], Gene ID: 4089, NCBI: NP_005350.1, UniProt: Q13485 |
| Catalog # | MBS476059 |
| Price | $335 |
| Order / More Info | Smad4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
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