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Antigenic Specificity | MYOC |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total MYOC antibody. Myocilin (MYOC), also known as TIGR or GLC1A, is a secreted glycoprotein of the olfactomedin family, originally identified in trabecular meshwork cells after prolonged treatment with glucocorticoids, and, independently, in the retina (PMID: 9176893; 9169133). It may participate in the obstruction of fluid outflow in the trabecular meshwork. Defects in MYOC are the cause of primary open angle glaucoma (POAG) (PMID: 21709622). MYOC has a molecular weight of 55-57 kDa, besides, a 66-kDa form, which could be a result of post-translational modifications, has also been reported in some researches (PMID: 9497363; 12150989). |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human MYOC. |
Other Names | [GPOA; JOAG; TIGR; GLC1A; JOAG1; myocilin] |
Gene, Accession # | [MYOC], Gene ID: 4653, NCBI: NP_000252.1, UniProt: Q99972 |
Catalog # | MBS9403905 |
Price | $255 |
Order / More Info | MYOC Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |