NT5E Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | NT5E |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ecto-5'nucleotidase (NT5E, also called CD73) is a 70 kDa glycosyl phosphatidylinositol-anchored membrane-bound glycoprotein that catalyzes the hydrolysis of extracellular nucleoside monophosphates into bioactive nucleoside (1). NT5E catalyzes the terminal step of extracellular adenosine formation from adenosine-monophosphate, therefore driving the regulation of extracellular adenosine levels and the downstream activation of the four G protein-coupled adenosine receptors (2). Binding of hypoxia-inducible factor (HIF-1) to the NT5E gene promotor leads to upregulation of NT5E during hypoxia (3). NT5E biological roles span from lymphocyte adhesion (4, 5), to fibrosis (6), to regulation of nociception (7, 8). |
| Immunogen | Immunogen: Recombinant protein of human NT5E Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [CD73; E5NT; NT; NT5; NTE; eN; Ent] |
| Gene, Accession # | [NT5E], Gene ID: 4907, NCBI: NP_001191742.1, UniProt: P21589 |
| Catalog # | MBS8500840 |
| Price | $310 |
| Order / More Info | NT5E Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Le Hir, M. and Kaissling, B. (1993) Am J Physiol 264, F377-87. 2. Schulte, G. and Fredholm, B.B. (2003) Cell Signal 15, 813-27. 3. Synnestvedt, K. et al. (2002) J Clin Invest 110, 993-1002. 4. Arvilommi, A.M. et al. (1997) Eur J Immunol 27, 248-54. 5. Airas, L. and Jalkanen, S. (1996) Blood 88, 1755-64. 6. Peng, Z. et al. (2008) Nucleosides Nucleotides Nucleic Acids 27, 821-4. 7. Sowa, N.A. et al. (2010) J Neurosci 30, 2235-44. 8. Zylka, M.J. (2011) Trends Mol Med 17, 188-96. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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