DISC1 (Disrupted in schizophrenia 1 protein)- (N-terminal) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DISC1 (Disrupted in schizophrenia 1 protein)- (N-terminal) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 0.1 mg |
| Concentration | 1ug/ul |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Disrupted-In-Schizophrenia 1 (DISC1) is associated with schizophrenia by multiple genetic studies. DISC1 might cause susceptibility to schizophrenia. DISC1 has distinct interaction domains: MAP1A interacts via its LC2 domain with the N-terminus of DISC1, whereas MIPT3 and NUDEL bind via their C-terminal domains to the central coiled-coil domain of DISC1, and ATF4/5 bind via their C-terminal domains to the C-terminus of DISC1. DISC1 protein localizes to predominantly perinuclear punctate structures which extend into neurites in some cells. DISC1 is a multifunctional protein whose truncation contributes to schizophrenia susceptibility by disrupting intracellular transport, neurite architecture and/or neuronal migration, all of which have been |
| Immunogen | Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of mouse DISC1 (Disrupted in schizophrenia 1 protein) |
| Other Names | [disrupted in schizophrenia 1 protein isoform S; Disrupted in schizophrenia 1 protein; disrupted in schizophrenia 1 protein; disrupted in schizophrenia 1], [DISC1; DISC1; SCZD9; C1orf136; KIAA0457] |
| Gene, Accession # | [DISC1], Gene ID: 27185, NCBI: NP_001012977.1, UniProt: Q9NRI5 |
| Catalog # | MBS418286 |
| Price | $445 |
| Order / More Info | DISC1 (Disrupted in schizophrenia 1 protein)- (N-terminal) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Morris, J.A., et al, Hum. Mol. Genet. 12 (13), 1591-1608 (2003) Ozeki, Y., et al, Proc. Natl. Acad. Sci. U.S.A. 100 (1), 289-294 (2003) Ozeki, Y., et al, Proc. Natl. Acad. Sci. U.S.A. 101, 13969-13969 (2004) Brandon, N.J., et al, Mol. Cell. Neurosci. 25 (1), 42-55 (2004) Brandon, N.J., et al, Mol. Cell. Neurosci. 28 (4), 613-624 (2005) Lipska, B.K., et al, Hum. Mol. Genet. 15 (8), 1245-1258 (2006) |
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