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Antigenic Specificity | MC1R |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma ski |
Immunogen | Immunogen: A synthetic peptide of human MC1R Calculated Molecular Weight: 35kDa |
Other Names | [CCL8: CMM5; MSH-R; SHEP2], [CCL8; CCL8; HC14; MCP2; MCP-2; SCYA8; SCYA10; MCP2; SCYA10; SCYA8; MCP-2] |
Gene, Accession # | [CCL8], Gene ID: 6355, NCBI: P80075.2, UniProt: P80075 |
Catalog # | MBS127054 |
Price | $200, $275, $430 |
Order / More Info | MC1R Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |