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Antigenic Specificity | Alpha-Catenin, Human |
Clone | 1G5 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Product Description: The monoclonal antibody 1G5 reacts with human alpha-catenin. Alpha-catenin belongs together with beta- and gamma-catenin to the catenin family. Catenins comprise a large family of Ca2 -dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Cadherins are single pass, type I transmembrane proteins that are localized in the adherens junction. To be fully functional, the cadherin cytoplasmic domain must be linked to the actin cytoskeleton through a group of proteins termed catenins: alpha-catenin, beta-catenin and plakoglobin. Alpha catenin interacts with the cadherin indirectly via interactions with beta-catenin or plakoglobin. |
Immunogen | n/a |
Other Names | [alpha-catenin, partial; Catenin alpha-1; catenin alpha-1; alpha-catenin; alphaE-catenin; alpha E-catenin; alpha-E-catenin; renal carcinoma antigen NY-REN-13; cadherin-associated protein,102kDa; catenin (cadherin-associated protein), alpha 1, 102kDa; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13], [CTNNA1; CTNNA1; CAP102] |
Gene, Accession # | Gene ID: 1495, NCBI: AAA35502.1 |
Catalog # | MBS584337 |
Price | $520 |
Order / More Info | Alpha-Catenin, Human Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Nieman, M et al; Mechanism of extracellular domain-deleted dominant negative cadherins. J Cell Science 1999, 112: 1621 2. Johnson, K et al; P- and E-cadherin are in separate complexes in cells expressing both cadherins. Exp Cell Res 1993, 207: 252 |