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Antigenic Specificity | SUN2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: SUN2 antibody detects endogenous levels of total SUN2. Function: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centr |
Immunogen | Immunogen: A synthesized peptide derived from human SUN2 Subcellular Location: Nuclear Membrane, Endosome Membrane, Mitotic Spindle Organization. Tissue Specificity: Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100% |
Other Names | [FRIGG; KIAA0668; nuclear envelope protein; Protein unc-84 homolog B; Rab5 interacting protein; RAB5IP; Sad1 and UNC84 domain containing 2; Sad1 unc-84 domain protein 2; Sad1 unc84 domain protein; Sad1/unc-84 protein-like 2; Sad1/unc84 protein-like; SUN domain-containing protein 2; UNC 84B; unc84 homolog B (C. elegans); unc84 homolog B; unc84, C. elegans, homolog of, B; UNC84B] |
Gene, Accession # | [SUN2], Gene ID: 25777, NCBI: NP_001186508.1, UniProt: Q9UH99 |
Catalog # | MBS9608768 |
Price | $240, $280 |
Order / More Info | SUN2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |