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Antigenic Specificity | NME1/nm23-H1/NDPK-A (Suppressor of Metastasis) |
Clone | [CPTC-NME1-2] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a, kappa |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP-K). In humans, NDP kinase A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human C-Myc promotor. |
Immunogen | Immunogen: Recombinant full-length human NME1 protein |
Other Names | [AWD; GAAD; Granzyme A activated DNase; Metastasis inhibition factor NM23; NB; NBS; NDP kinase A; NM23 long variant; included; NM23H1B; NME/NM23 nucleoside diphosphate kinase 1; NME1-NME2 spliced read-through transcript; included; Non-metastatic protein 23; homolog 1; Nucleoside diphosphate kinase A; Tumor metastatic process-associated protein] |
Gene, Accession # | [NME1], Gene ID: 4830, NCBI: NP_000260.1, UniProt: P15531 |
Catalog # | MBS4381120 |
Price | $190, $340, $340 |
Order / More Info | NME1/nm23-H1/NDPK-A (Suppressor of Metastasis) Antibody from MYBIOSOURCE INC. |
Product Specific References | Steeg, P.S., et al. 1988. J. Natl. Cancer Inst. 80: 200-209 |