Rat CD8a, Low Endotoxin Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Rat CD8a, Low Endotoxin |
| Clone | OX-8 |
| Host Species | Mouse |
| Reactive Species | rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.5 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), Immunoprecipitation (IP), WB, Immunohistochemistry (IHC) Frozen/Paraffin, Functional Studies, Depletion |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The anti-rat T cytotoxic/suppressor cell monoclonal antibodies recognize a determinant on the majority of thymocytes (90-95%), a subset of peripheral T cells, the majority of NK cells, and the granular intraepithelial leukocytes in the small intestine (1,2,3,4). The antigen recognized is a complex of surface glycoproteins of Mr 34, 39, and 76 kDa and is the rat homologue of the human CD8 and the mouse Ly 2.3 antigen (5,8). Clone OX-8 labels all peripheral T cells that are unlabelled by clone W3/25 (CL003). It labels a T cell subset which mediates the suppression of antibody formation (1) and the cytotoxic cell precursor (2). OX-8 and W3/25 can be used together to fractionate T cells by sorting in FACS or by rosette depletion (1,2) or can be |
| Immunogen | n/a |
| Other Names | [CD8a molecule; T-cell surface glycoprotein CD8 alpha chain; CD8a molecule], [CD8A; CD8; p32; Leu2] |
| Gene, Accession # | [CD8a], Gene ID: 925, NCBI: AAH25715.1 |
| Catalog # | MBS520872 |
| Price | $385 |
| Order / More Info | Rat CD8a, Low Endotoxin Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1) Brideau, R.J., Carter, P.B., McMaster, W.R., Mason, D.W. and A.F. Williams. (1980) Eur. J. of Immunol. 10, 609-615. Two subsets of rat T lymphocytes defined with monoclonal antibodies. 2) Dallman, M.J., Mason, D.W. and M.Webb. (1982) Eur. J. Immunol. 12, 511-518. The role of host and donor cells in the rejection of skin allografts by T cell deprived rats infected with syngenic T cells. 3) Cantrell, D.A., Robins, R.A.,Brooks, C.G. and R.W. Baldwin. (1982) Immunology. 45, 97-103. Phenotype of rat natural killer cells defined by monoclonal antibodies marking rat lymphocyte subsets. 4) Lyscom,N. and M.J. Brueton. (1982) Immunology. 45, 775-783. Intraepithelial lamina propria and Peyer's patch lymphocytes of the rat small intestine: isolation and characterization in terms of immunoglobulin markers and receptors for monoclonal antibodies. 5) Johnson, P., Gagnon, J., Barclay, A.N. and A.F. Williams. (1985) EMBO J. 4, 2539-2545. Purification, chain separation and sequence of the MRC OX-8 antigen, a marker of rat cytotoxic T lymphocytes. 6) Barclay,A.N. (1981) Immunology, 42, 593-600. The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues. 7) Mason, D.W. (1981) Transplantation, 32, 22-226. Subsets of T cells in rat mediating lethal graft vs. host disease. 8) Thomas, M.L. and J.R. Green. (1983) Eur.J. Immunol. 13, 855-858. Molecular nature of the W3/25 and MRC OX-8 marker antigens for rat T lymphocytes; comparisons with mouse and human antigens. 9) Whiteland, J.L et al (1995). Immunohistochemical detection of T cell subsets and other leukocytes in paraffin embedded rat and mouse tissues with monoclonal antibodies. J. Histochem. Cytochem. 43: 313-320. |
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MYBIOSOURCE INC.
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