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Antigenic Specificity | FASL |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Fas and Fas Ligand (FASL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FASL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FASL-induced apoptosis by acting as a decoy receptor that serves as a sink for FASL. |
Immunogen | Immunogen: FASL antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human FAS-L, different from the related Rabbit sequence by two amino acids, and from the related rat sequence by three amino acids, as the immunogen |
Other Names | [Affinity Purified Goat FASL; FASL; FASL; TNFSF6; sFASL; Apo I Ligand; CD95L; APTL; soluble Fas Ligand] |
Gene, Accession # | [FASL], Gene ID: 102178753 |
Catalog # | MBS5312585 |
Price | $345 |
Order / More Info | FASL Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |