AGRN Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | AGRN |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: AGRN antibody detects endogenous levels of total AGRN. Function: Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic proces |
| Immunogen | Immunogen: A synthesized peptide derived from human AGRN Subcellular Location: Cell Junction, Synapse. Cell Membrane and Secreted, Extracellular Space, Extracellular Matrix. Synaptic basal lamina at the neuromuscular junction. Tissue Specificity: Expressed in basement membranes of lung and kidney. Muscle-and neuron-specific isoforms are found. Isoforms (y ) with the 4 AA insert and (z 8) isoforms with the 8 AA insert are all neuron-specific. Isoforms (z 11) are found in both neuronal and non-neu |
| Other Names | [AGRIN; Agrin proteoglycan; AGRN; FLJ45064; OTTHUMP00000044043] |
| Gene, Accession # | [AGRN], Gene ID: 375790, NCBI: NP_001292204.1, UniProt: O00468 |
| Catalog # | MBS9609498 |
| Price | $240, $280 |
| Order / More Info | AGRN Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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