PHF19 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PHF19 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: PHF19 antibody detects endogenous levels of PHF19. Function: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcrip |
| Immunogen | Immunogen: A synthesized peptide derived from human PHF19. Subcellular Location: Nucleus. Tissue Specificity: Isoform 1 is expressed in thymus, heart, lung and kidney. Isoform 2 is predominantly expressed in placenta, skeletal muscle and kidney, whereas isoform 1 is predominantly expressed in liver and peripheral blood leukocytes. Overexpressed in many types of cancers, including colon, skin, lung, rectal, cervical, uterus, liver cancers, in cell lines derived from different stages of melanoma a |
| Other Names | [hPCL3; MGC131698; MGC149712; MGC149713; MGC23929; MTF2L1; OTTHUMP00000021996; OTTHUMP00000021998; PCL3; PHD finger protein 19; Phf19; PHF19 protein; PHF19_HUMAN; Polycomb like 3; Polycomb like protein 3; Polycomb-like protein 3; TDRD19B; Tudor domain containing 19B] |
| Gene, Accession # | [PHF19], Gene ID: 26147, NCBI: NP_001009936.1, UniProt: Q5T6S3 |
| Catalog # | MBS9603680 |
| Price | $240, $280 |
| Order / More Info | PHF19 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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