CD137, Mouse Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CD137, Mouse |
| Clone | [LOB12] |
| Host Species | Rat |
| Reactive Species | mousedoes not react with human. |
| Isotype | IgG2a, kappa |
| Format | purified |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | Functional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adh |
| Immunogen | Immunogen: Murine CD137 human Fc fusion protein |
| Other Names | [4-1BB ligand receptor; 4-1BB; Mouse; homolog; CD137; HLDA VI; induced by lymphocyte activation (ILA); Interleukin activated receptor homolog of Mouse Ly63; Ly63; Mouse; Receptor protein 4 1BB; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)] |
| Gene, Accession # | [CD137], Gene ID: 21942, NCBI: NP_001070977.1, UniProt: P20334 |
| Catalog # | MBS4381535 |
| Price | $190, $340, $340 |
| Order / More Info | CD137, Mouse Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Taraban, V. Y., et al. (2002). Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses. Eur J Immunol 32(12): 3617-3627. 2. Bartkowiak, T., et al. (2015). Unique potential of 4-1BB agonist antibody to promote durable regression of HPV tumors when combined with an E6/E7 peptide vaccine. Proc Natl Acad Sci U S A 112(38): E5290-5299. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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