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Antigenic Specificity | Caspase 10 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Caspase 10 antibody detects endogenous levels of total Caspase 10. Description: Casp10 Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas-and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and-9. Hydrolyzes the small-molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Belongs to the peptidase C14A family. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit. Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex |
Immunogen | Immunogen: A synthesized peptide derived from human Caspase 10 Tissue Specificity: Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. Predicted Cross Reactivity: Horse, Rabbit, Xenopus Similarity: Horse (100%), Rabbit (86%), Xenopus (86%) |
Other Names | [ALPS2; Apoptotic protease Mch-4; CASP 10; CASP-10; CASP10; CASPA_HUMAN; Caspase 10 apoptosis related cysteine peptidase; Caspase-10 subunit p12; FADD like ICE2; Fas associated death domain protein; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE 2; FLICE2; ICE like apoptotic protease 4; ICE-like apoptotic protease 4; Interleukin 1B converting enzyme 2; MCH 4] |
Gene, Accession # | [CASP10], Gene ID: 843, NCBI: NP_001193453.1, UniProt: Q92851 |
Catalog # | MBS9600060 |
Price | $240, $280 |
Order / More Info | Caspase 10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |