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Antigenic Specificity | HNMT |
Clone | [432CT31.4.2] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Purified His-tagged HNMT protein(Fragment) was used to produced this monoclonal antibody. In mammals, histamine is metabolized by two majorpathways: N(tau)-methylation via histamine N-methyltransferase andoxidative deamination via diamine oxidase. This gene encodes thefirst enzyme which is found in the cytosol and usesS-adenosyl-L-methionine as the methyl donor. In the mammalianbrain, the neurotransmitter activity of histamine is controlled byN(tau)-methylation as diamine oxidase is not found in the centralnervous system. A common genetic polymorphism affects the activitylevels of this gene product in red blood cells. Multiplealternatively spliced transcript variants that encode different |
Immunogen | n/a |
Other Names | [Histamine N-methyltransferase; HMT; HNMT] |
Gene, Accession # | [HNMT], Gene ID: 3176, NCBI: NP_001019245.1, UniProt: P50135 |
Catalog # | MBS9200455 |
Price | $370 |
Order / More Info | HNMT Antibody from MYBIOSOURCE INC. |
Product Specific References | Stevenson, J., et al. Am J Psychiatry 167(9):1108-1115(2010) Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010) Davila, S., et al. Genes Immun. 11(3):232-238(2010) |