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Antigenic Specificity | Human ATG5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Peptide Affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | ATG5 is required for autophagy. It conjugates to ATG12 and associates with isolation membrane to form autophagosomes. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (1). Conjugation to ATG12 is essential for autophagy, but is not required for association with isolation membrane. ATG5 also plays an important role in the apoptotic process. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. ATG5 is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-1 conjugation to PE to form LC3-II (2). |
Immunogen | Immunogen: Synthetic peptide from the N-terminal of human ATG5. Immunogen Species: Human |
Other Names | [APG5-like; ASP; hAPG5; ATG5 : RPE; Rabbit Human ATG5; Rabbit Human ATG5; ATG5], [ATG5; ATG5; ASP; APG5; APG5L; hAPG5; APG5-LIKE; APG5L; ASP] |
Gene, Accession # | [ATG5], Gene ID: 9474, NCBI: NP_001273035.1, UniProt: Q9H1Y0 |
Catalog # | MBS807391 |
Price | $435 |
Order / More Info | Human ATG5 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Pyo J.O., et al. (2005) J Biol Chem. 280(21): 20722-20729. 2. Mizushima N., et al. (2003) Mol Biol Cell. 15(3): 1101-1111. |